Journal: Journal of translational medicine
Article Title: TET3-facilitated differentiation of human umbilical cord mesenchymal stem cells into oligodendrocyte precursor cells for spinal cord injury recovery.
doi: 10.1186/s12967-024-05929-7
Figure Lengend Snippet: Fig. 5 Transcriptome analysis of the role of TET3 in HUCMSC differentiation towards oligodendrocyte progenitor cells (OPCs). a Heatmap showing upregulation of genes promoting oligodendrocyte lineage formation and differentiation and downregulation of inhibitory genes. b Correlation analysis between TET3 expression and multiple genes related to the oligodendrocyte lineage. c–g Positive correlation between TET3 and (c) APC, (d) SOX5, (e) ASH1L, (f) GALC, and (g) IGF1. h–j Negative correlation between TET3 and (h) IL1B, (i) ENG (CD105), and (j) NT5E (CD73). k Suppression of pathways inhibiting oligodendrocyte lineage formation during differentiation. l Negative correlation between TET3 and the Wnt signaling pathway
Article Snippet: Expression of surface markers CD73 (13160, Cell Signaling Technology), CD105 (4335, Cell Signaling Technology), immunoglobulin (Ig)G1 (5415, Cell Signaling Technology), IgG2a (61656, Cell Signaling Technology), CD45 (13917, Cell Signaling Technology), and HLA-DR (78397, Cell Signaling Technology) were identified by flow Cytometer (FACSA Canto II; BD Biosciences, USA).
Techniques: Expressing